PSYC 462 Lecture Notes - Lecture 9: Long-Term Potentiation, Ketamine, Autoreceptor
Document Summary
Psyc 462 002 lecture notes 1st february 2018. Chapter 8: glutamate and gaba amino acid transmitters: glutamate. Requires coagonists glycine and d-serine to bind in order to open na+ channels. Depolarization must happen in order for mg2+ to get out of plugged pore. Competitive antagonists work at the same site where glutamate binds. A higher concentration leads to greater blockage of glutamate. Pcp, ketamine and mk801 go inside ion pore and plug channel. When site is blocked, any amount of glutamate would not activate receptor. Most neurons with glutamate receptors have both ampa and nmda receptors but these two work differently. Nmda receptors have longer duration of effect than ampa. When both types of receptor work together, there is much greater depolarization and also regulation of pattern firing. Two types of firing are i) burst pattern and ii) single-spike steady stream mode. They make neurons more effective at releasing neurotransmitters.
