PHRM 451 Lecture Notes - Lecture 5: Hirsutism, Teratology, Gabapentin
Document Summary
Estrogen-dependent inflammatory disease (chronic and recurring) characterized by the presence of endometrial tissue outside the uterus (most commonly ovaries, pelvic peritoneum) Endometriosis is a common cause of chronic pelvic pain (35%) and infertility (38%). Pain fluctuates with cycle higher estrogen levels = more pain. First-line treatment for mild pelvic pain and dysmenorrhea. Avoid in renal disease, peptic ulcer, chf, asthma. First-line treatment for mild pelvic pain +/- nsaids. Low dose oc (20-35 mcg ethinyl estradiol + progestin) Suggested to use monophasic because products that aren"t monophasic have varying levels of progestin or estrogen which can cause flare ups. Alesse oc with a low amount of ee is suggested. Cyclic = worsening of symptoms during 7 day break period -so continuous recommended. Nausea, bloating, breast tenderness, mood changes, thrombosis, breakthrough bleeding. An option if ocs not effective or contraindicated. Osteoporosis with mpa im (long-term use) should also be taking ca and vit d.
