PHRM 311 Lecture Notes - Lecture 22: University Of Manchester, Morphine, Risperidone
Document Summary
Target lowest dose that relieves withdrawal symptoms and suppresses illicit drug use. If switching from illicit opioid (e. g. daily heroin use) Titrate up based on patient"s withdrawal symptoms every 2 days. Start with 1:4 methadone to slow-release morphine dose and titrate up based on patient"s withdrawal symptoms every 2 days. Ultimate dose conversion will be somewhere between 1:6 to 1:8. If missed dose , must be very careful with continuing therapy given short half-life (dose adjust if > 2 days missed) Recommended to open capsule and sprinkle pellets in paper cup swallow them with a cup of water or mix with apple sauce ( decrease risk of diversion ) Do not crush, chew, or dissolve capsule or pellets. Heroin positive urine drug screens : no statistically significant difference. One found more physical complaints with srom. Other no difference between adverse effects of srom and methadone. 2 found improvement in mental health symptoms (i. e. anxiety, depression scores) with srom.
