PHRM 311 Lecture Notes - Lecture 16: Atypical Antipsychotic, Paliperidone, Valproate
Document Summary
Differences in dosing between schizophrenia and bipolar disorder. Acute mania: ir 100-200 mg once daily at bedtime. Acute depression: ir 50 mg once daily at bedtime. Differences in efficacy between individual agents for certain mood states. She has recently been diagnosed with bipolar depression. Her family doctor puts her on divalproex 500 mg po bid. Cbc, liver function tests, valproic acid level (blood tests q3-6 months) Hair, mse, n/v, tremors, rash (changes in mood) Combination treatment provide greater response rates, but greater ses burden. Manage comorbid agitation with acute agitation therapeutics. Test drove a sports car and tried to fast and furious it on the freeway . Sleeping 2 hours, working out 6 hours a day. What will you recommend for bo"s mania? profile. Lithium 300 mg po twice daily also correct, best evidence for maintenance. Quetiapine long-acting 200 mg po daily with dinner better long term safety. Divalproex tablet 500 mg po daily also an option.
