PHRM 221 Lecture Notes - Lecture 25: Multivitamin, Subgroup Analysis, Micronutrient
Document Summary
Heavily publicized rct of 14,641 men (mean age 64. 3) randomized to centrum silver or placebo, followed 11. 2 years. Multiple issues lots of exclusion including run-in to remove non-compliant patients, adjustments (without clear reason) always in favor of multivitamins. Consider study population (4% smokers, 76% used asa, all well-nourished) Meta-analysis of 21 rcts with 91,074 patients (54% male) Mostly european, n. american primary prevention studies. Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life: cochrane review. Most studies were not designed primarily to assess cognition and thus lacked baseline cognitive assessments. Most studies had follow-up < 5 years may not be long enough to see cog decline. Most studies had a mean age > 60 yo. Daily mv have also been studied (rcts) for. Self-reported infection, primary care visits for infection, qol no effect. Incidence and severity of arti no effect.
