PHRM 221 Lecture Notes - Lecture 18: Cyp1A2, Cyp3A4, Amiodarone
Document Summary
Definition : the result of a physical, chemical, physiologic, or pathophysiologic relationship between a drug and nutrient status, a nutrient, multiple nutrients, or food in general. Majority of recommendations are made by product-specific manufacturers. Most pk/pd data in special populations pertain to renal and hepatic dysfunction. May be difficult to find information that pertains to populations at risk of drug-nutrient interactions. Decreased physiologic reserve (critically ill patients, elderly, malnourished) Interactions between a drug and drug/nhp/nutrient/food are based on: pharmaceutical. Involve physiochemical reactions that take place within delivery devices (e. g. enteral feeding tubes) or within the gi lumen. Example : chelation of ciprofloxacin in an enteral formula: pharmacodynamic, pharmacokinetic. Involve the clinical effect of a drug or physiologic effect of a nutrient. Example : warfarin and vitamin e increase bleeding risk (additive) Defined by changes in relevant parameters (e. g. bioavailability, vd, clearance) May involve transporters or enzymes important for adme (p450 enzymes or.
