PHRM 221 Lecture Notes - Lecture 3: Malabsorption, Prostate Cancer, Warfarin
Document Summary
Alpha-tocopherol : found in greatest amounts in circulation and tissues. Dietary sources : vegetable oils, nuts, whole grains (contain the active rrr-a-tocopherol ) Only 4 of 8 stereoisomers are biologically active. A given amount of the synthetic vitamin is only 50% as active as the natural one. Supplements are sold as esters of either natural or synthetic vit e. 1 iu natural vit e = 0. 67 mg rrr-a-tocopherol. 1 iu synthetic vit e = 0. 45 mg rrr-a-tocopherol. Lipid-soluble antioxidant suggested to protect cell membranes against oxidative damage by free radicals. Neurological symptoms and anemia responsive to vit e found in premature infants. Normally symptomatic dietary deficiency is not seen. and children with fat malabsorption syndromes. Ul of vitamin e: 1000 mg/day of alpha-tocopherol (any form) Based on possibility that high doses of vit e may have anticoagulant activity and could cause hemorrhage. Increased risk of bleed co-administration of vit e and warfarin.
