PHRM 211 Lecture Notes - Lecture 27: Disinhibition, Vitamin B12 Deficiency, Cerebrovascular Disease
Document Summary
Full physical and mental status examination to help identify the cause. Assess for reversible medical illnesses (e. g. vitamin b12 deficiency, hypothyroidism) Neuro : look for signs of parkinsonism (e. g. tremor, bradykinesia, rigidity, postural instability, changes in speech) Lab tests : cbc, fasting glucose, electrolytes, tsh, b12, folate, renal function. Mini-mental status exam (mmse) alone or in combination with clock drawing test. Ascertain dementia-8 (ad-8), alone or in combination with mini-cog. Sensitivity as a screening tool for mild cognitive impairment. Can provide method of monitoring deterioration over time education due to language and math elements. Length of administration time (minimum 15 min) Biased against patients with poor education due to language and math elements. Accumulation of amyloid plaques (beta-amyloids) and neurofibrillary tangles (tau proteins) neurodegeneration. Aggregates of alpha synuclein proteins (lewy bodies) in brain stem, limbic, and cortical regions causing neuronal loss. Frontotemporal accumulation of abnormal deposits of intracellular proteins leading to neurodegeneration.
