PHRM 211 Lecture Notes - Lecture 25: Curcumin, Tau Protein, Senile Plaques
Document Summary
Pathophysiology & pharmacology of dementia (part 1) Dementia : a major neurocognitive disorder, in which a deficit in cognitive functioning characterized by the following common symptoms occurs. A neurodegenerative disorder marked by cognitive and behavioral impairment that significantly interferes with one"s social and occupational functioning. Definitive diagnosis by autopsy or brain biopsy. Greater than half (60-70%) of dementia cases result from ad. Abnormalities in three genes ( app , psen1 , and psen2 ) are known to cause ad. Autosomal-dominant forms of ad tend to be severe occurring at a younger age than sporadic form of ad. Sporadic form of ad accounts for the majority of ad. Nutritional factors (curcumin, green tea, mediterranean diet, omega-3 fatty acids, red wine - moderate amt) Healthy neurons contain support structures microtubules guide nutrients/molecules from the cell body along the axon to the neuron terminal and back again to the cell body. Tau protein ( ) binds to and stabilize the microtubules.
