PHRM 211 Lecture Notes - Lecture 11: Neuropathic Pain, Phantom Limb, Nociception
Document Summary
Pathophysiology of acute and chronic pain (part 1) Pain : an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. Definition: pain which arises from acute injury or disease process and exists only as long as tissue pathology. Usually most intense at the onset of injury and subsides as healing occurs. Examples: cut or burn to the hand, postoperative pain. Definition: pain lasting more than 6 months. May be associated with chronic tissue pathology (e. g. arthritis) May exist beyond the normal healing period for an acute injury (e. g. neuropathic pain arising from nerve damage) Doesn"t have any useful purpose and is often difficult to treat. Definition: pain originates at nociceptors (located at nerve terminals) of certain types of fibres which are activated by a noxious (painful) stimulus. Definition: pain resulting as a consequence to peripheral nerve damage. May have both nociceptive and neuropathic components.
