PHRM 211 Lecture Notes - Lecture 10: Sleep Onset Latency, Zopiclone, Eszopiclone
Document Summary
Marketed as non-bdz drugs, but bdz-receptor agonists. Work on a subset of the bdz receptor ( 1 subunit) Eszopiclone is the active isomer of zopiclone (not available in canada) Dosage (oral): 3. 75-7. 5 mg qhs (max 5 mg in 65 or patients with kidney/liver disease) t1/2 : 6 hours. Di : minimal additive effects with low doses of alcohol. 65 : 5 mg qhs t1/2 : 2. 5 hours. Adr : complex sleep behaviours (e. g. night eating , sleepwalking ) esp females and elderly. Gender and age-based differences in metabolic clearance. Sleep onset latency by 13-22 min. Total sleep time by 5% (compared to cbt improves by. Start at lowest effective dose for short duration (1 week), up. Remember the different doses for zolpidem (lower starting doses for females and elderly) gender and age-based differences in metabolic clearance. Risk of mild infections and have some inconsistent cognitive effects (e. g. reduced verbal memory or attention) Complex sleep behaviours with zolpidem (females, elderly)
