PHRM 211 Lecture Notes - Lecture 20: Bicarbonate Buffer System, Carbonic Anhydrase, Proximal Tubule
Document Summary
20. 1 acid base disorders interpretation of arterial blood gases. Ability of a system to maintain ph within a narrow range when an acid or base is added to it. Typically incompatible with life < 6. 8 or > 7. 8. Renal excretion of non-volatile acids and regulation of bicarbonate (phosphates, ammonia) Approximate 80-90% bicarbonate is reabsorbed in the proximal tubule . The bicarbonate buffer system is our most important physiologic buffer system because we can easily regulate it through removal or retention of co 2 via our pulmonary system. Cvs arrhythmias, hypotension , cardiac failure arrhythmias, cardiac failure. [base] ph = pka + log [acid] ph = 6. 1 + log 10 ([hco 3 . Gold standard for monitoring acid-base status and oxygenation. Paco2 = 40 mmhg ph = 6. 1 + log ([hco3-] / [0. 03 x paco2]) ph = 6. 1 + log ([10] / [0. 03 x 40]) ph = 6. 1 + 0. 92 ph = 7. 02.
