PHRM 111 Lecture Notes - Lecture 5: Enoxaparin Sodium, Dabigatran, Rivaroxaban
Document Summary
Goal: to diminish the risk of dvt and pe. Involves using lower doses of anticoagulant medications (than treatment) to prevent the development of a first or new vte in a patient at high risk of vte. Given for relatively short periods of time (e. g. during hospital stay) Patient receives the full treatment dose of a particular anticoagulant. Also used for the prevention of cardioembolic events (e. g. stroke) in atrial fibrillation. Heparin iv continuous infusion adjusted to aptt target. Uncommon in patients < 40 years old and in those with no risk factors. Patients with multiple prior vtes are usually given extended/indefinite full-dose anticoagulation (not vte prophylaxis) Pe is the most common preventable cause of death in hospitalized adult patients. In hospital, multiple vte risk factors come together e. g. patient factors (age, chronic medical conditions), immobility, trauma, surgery, acute illness. Relies on clinical trial evidence and weighing of data from multiple sources.
