PHAR 471 Lecture Notes - Lecture 6: Coronary Artery Disease, Heart Failure, Coronary Circulation
6 Nov 2016
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Document Summary
Atherosclerosis: know about the metabolism of cholesterol, understand lipoprotein biology (e. g. ldl and hdl) and their role in cardiovascular disease, describe the mechanism of atherosclerosis. Chd: occlusion of blood flow through some part of the coronary arteries. Myocardial infarct: dead heart muscle caused by lack of blood flow. Cardiovascular mortality accounts for 30-50% of all deaths in the developed nations. Most of these deaths are caused by atherosclerosis, which is responsible for more deaths than cancer, accidents, chronic lung disease and diabetes combined. (left and right branches) supply blood to the heart muscle itself. Restricted blood flow to the myocardium may be caused by an atherosclerotic plaque narrowing the lumen of coronary arteries. If the diameter of the lumen is reduced by more than 50%, ischemia will develop and the patient will develop tightness or pain the chest. However, pan does not always accompany myocardial ischemia (silent ischemia)
