PHAR 460 Lecture Notes - Lecture 11: Epimedium, Benign Prostatic Hyperplasia, Serenoa
10 Dec 2016
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Ipss < 7 = mild lifestyle only. Ipss 8-18 = moderate; ipss 19-35 = severe alpha blockers (abs) +/- 5-alpha reductase-inhibitors (5aris), surgery. Abs: first dose fainting, ejaculation disorder, dizziness, hypotension, headache, intraoperative floppy iris syndrome. 5aris: reduced psa levels, risk of severe prostate cancer, impotence, ejaculation disorder, breast enlargement. Improving efficacy: only modest efficacy from abs and 5aris. Saw palmetto serenoa repens, sabal serrulatum, southeastern usa. Health canada says to standardize it to saw palmetto fruit lipidosterolic extract 70-95% fatty acids. Health canada: allowed claim for bph symptom relief as herbal medicine. Ppp-nn past studies, poor quality, positive results; new studies, negative results. 2000 and before: studies said that it reduces ipss and improves urine flow rate. But 2012 ma says it"s no different from placebo = higher quality studies. Current evidence does not support any benefit beyond that of a placebo.
