PHAR 441 Lecture Notes - Lecture 3: Hypogonadism, Bone Density, Cyproterone
14 Sep 2016
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Identify the major therapeutic uses and adverse effects of androgens. 4: describe the various androgen preparations available, describe the mechanisms of action, major therapeutic uses and side-effects of the anti-androgens and 5 -reductase inhibitors. The most physiologically important androgen in the body = testosterone (all that we are talking about) Men: testes (~95%) and adrenal glands (~5%) Women: small amount in the ovaries and adrenal glands. Conversion of cholesterol to pregnenolone occurs in the mitochondria. All other steps occur in the smooth er. Testes make about 6-8 mg of testosterone per day. Leydig cells make up 5% of cells in the testes there are ~500 million leydig cells in the testes. Development of male sex organs, prostate, seminal vesicles, spermatogenesis, sexual function. Larynx growth and voice deepening increases linear bon growth; also helps terminate bone growth and maintaining bone density. Induce and/or maintain pubertal development (including secondary sex characteristics)
