PHAR 441 Lecture 11: 11. Antiplatelets, Anticoagulants, Thrombolytics
10 Dec 2016
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List the anticoagulants commonly used and understand their mechanism of action and adverse effects. Hemostasis = cessation of blood loss from a damaged vessel (arrest of bleeding) Process: constriction of blood vessels to limit blood loss contribution from platelets and coagulation proteins to form a thrombus (blood clot) Thrombus = clot adheres to the interior wall of an artery or vein. Embolus = clot that dislodges and travels in the blood stream. Thrombosis = formation of an unwanted clot in arteries or veins. Ischemia, mi, angina, stroke, or peripheral arterial disease. Adherence of platelets to the arterial wall due to platelet activation. Pale, granular and have a lower cell count. Activation of the clotting system develops in an area of stagnated blood flow. Soft, deep red and have a higher cell count. Injury = secretion of vasoconstrictors (like endothelin-1) = local vasoconstriction causes primary hemostasis. Anucleate, cellular fragments that circulate as inactive, non-binding concave discs.
