PHAR 441 Lecture Notes - Lecture 16: Pernicious Anemia, Folate Deficiency, Renal Medulla
10 Dec 2016
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Requirements (note focus on these things lots of questions) Requires a constant supply of three essential nutrients iron, vitamin b12, and folic acid. The decreased ability of the rbcs to carry adequate oxygen to different tissues. Production from undifferentiated stem cells of circulating erythrocytes, platelets and leukocytes. Anemia due to folic acid deficiency (folate deficiency anemia) Anemia due to vitamin b12 deficiency (pernicious anemia) Iron levels are too low to make hemoglobin. Iron forms the nucleus of the iron-porphyrin heme ring. Found mainly in hemoglobin (the major protein in erythrocytes) Recommended dietary allowances (rda) = 7-27 mg/day of elemental iron. Assuming at least 10% is in the heme form. Absorption: 5-10% or about 0. 5-1 mg daily: note: rda has been set based on the absorption rates. Heme iron contributes an average dietary iron bioavailability of 18% Efficiently absorbed intact heme iron in meat hemoglobin and myoglobin is taken up by gi epithelial cells (hcp-1)
