PHAR 435 Lecture Notes - Lecture 9: Levonorgestrel, Norgestrel, Chlormadinone Acetate

• School: UBC
• Department: Pharmaceutical Sciences
• Course: PHAR 435
• Professor: Stelvio Bandiera

Document Summary

Identify (by name, location on the molecule, and chemical structure) two functional groups that increase receptor binding over that of progesterone and two modifications that reduce receptor binding relative to progesterone. Identify (by name, chemical structure, and location on the steroid molecule) at least one structural modification that allows progestins to be active when taken orally. (androgen or gonane backbone + ethynyl group) Identify (by name and chemical structure) one or more structural modifications that result in decreased androgenic activity. Primary site of action = the uterus (endometrium and myometrium) Also involved in the formation of the placenta and development of mammary glands. Produced primarily in the ovaries (adrenal cortex produces much smaller amounts) Reproductive age: progesterone is secreted by the corpus luteum during the latter half of the ovulatory cycle. Pregnancy: placenta takes over as the major source of progesterone. Men: produced in the testes and adrenal cortex as a precursor of the adrenal steroids.