PHAR 435 Lecture Notes - Lecture 5: Cyclic Adenosine Monophosphate, Guanfacine, Decarboxylation
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Learning objectives: recognize and be able to draw the general structure of a catecholamine. 2: outline and discuss the metabolism of norepinephrine and structural changes that lead to effective agonists with longer duration of. 1, 2, 1 and 2 adrenergic receptors don"t memorize the drug structures, but recognize what each part of the molecule is important for: describe the mechanism of inhibition of dopa decarboxylase by carbidopa. Chemical agents that enhance or interfere with the action of ne (major nt of the sympathetic system) Ne = the neurotransmitter of postganglionic sympathetic neurons (i. e. peripheral sympathetic neurons) Ne is released from sympathetic nerve endings into the synaptic cleft interacts with pre- and post- synaptic adrenergic receptors. Not released from peripheral sympathetic nerve endings synthesized and stored in the adrenal medulla where it is released into the circulation often referred to as a neurohormone (a)