PHAR 430 Lecture Notes - Lecture 7: Relative Permittivity, Bioisostere, Dielectric
Document Summary
Mh: we should become accustomed to seeing chemical structures with different modifications as these alterations will be continuously discussed throughout the term. Once we get an idea of the relative contributions of different types of interactions, then it will be easier for us to rationalize specific modifications to a compound"s structure. Sar studies research carried out to determine those atoms and/or fxnal groups that are most important to a molecule"s activity. The molecules that make up us (dna, sugars, lipids) have been modified through evolution to optimize fxn, some modifications are effective, some aren"t. I. e. molecules dna/rna (a, g, t/u, c, non-natural nucleotides), proteins (natural 20 amino acid variants, unnatural amino acids), sugars (stereochemistry, branching, etc. ), lipids (chain length, level of unsaturation, etc. ), drugs (basic structure plus added substituents, molecular pieces or building blocks) Pharmacophore atoms & fxnal groups required for specific pharmacological activity, and their relative positions in space.
