PHAR 315 Lecture Notes - Lecture 9: Doseone, Exponential Function, Reaction Rate Constant
23 Feb 2016
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We consider the body as a single well-mixed container: one compartment. Assume that the drug in the blood is in rapid equilibrium with the drug in extravascular tissues. The drug concentration might not be equal in each tissue or fluid, but we assume that all drug concentrations are proportional to the [drug] in the blood at all times. This isn"t an exact representation, but it"s useful for a number of drugs: rapid mixing. Assume that the drug is mixed instantaneously in blood or plasma. The actual time for mixing is usually very short (few mins), and we usually don"t sample enough (normal sampling time = hours) to see drug mixing in the blood. Assume that drug elimination follows 1st order kinetics such that the rate of change of [drug] by any process is directly proportional to the [drug] remaining. 1st order kinetics is an assumption of a linear model and not a one compartment model.
