PHAR 315 Lecture Notes - Lecture 8: Horse Length, Bioavailability
23 Feb 2016
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Document Summary
Calculating the relative efficiency of different drug products. Gives us another method to calculate the vd (instead of measuring it from plasma concentration at time zero . Auc = the sum of all segments together. Each narrow segment has an area = cp x dt thus the total area area auc has the. Auc from time zero to the last plasma sample is determined as a number of trapezoids. The area from the last data point (clast) to infinite time is calculated as: Kel is calculated from the slope of the ln(concentration) vs. time plot, And we already know that t1/2 = 0. 693/k. You just have to take bioavailability into account for clearance: Comparing oral to iv: cloral = cliv/f, vdoral = vdiv/f i. e. you modify by f. If f is at or very close to 100%, then oral dosing can be used to determine cl and vd; if not, then iv must be used to find these values.
