PHAR 201 Lecture Notes - Lecture 21: Testicular Atrophy, Stanozolol, Strychnine
16 Dec 2015
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Document Summary
Biking scandals of the late 1990s made an anti-doping agency necessary, founded in lausanne in 1999. If 2/3 criterion met, drug is banned. operate a cat-and-mouse game arms race with cheater. Describe and classify the classes of peds. What are anabolic steroids: cns effects to reduce muscle tiredness/fatigue, increase cv activity (bp + hr, enhance stamina + competitiveness, cv (arrthymia, hypertension len bias?, cns (anxiety, psychosis tremor) Effect: bind to receptors in cell nuclei to stimulate protein production: aids cell repair + muscle synthesis. Side effects: cardiac hypertrophy/arrest, mood disorder, Virilisation, infertility in women, testicular atrophy, sterilization in men (b/c decrease in endogenous testosterone production) Increase urine production greater loss of fluid, electrolyte, metabolic waste, and drugs. Clinical effect: hypertension, heart failure, and kidney/lung disease. Sports effects: quick loss of water weight (boxing, mma, etc, masking agent: dilution effect, no actual performance enhancing effect.
