PHAR 201 Lecture Notes - Lecture 16: Neuromuscular Junction, Muscle Relaxant, Myalgia
16 Dec 2015
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Not the ones advertised on tv (those are mild sedatives mixed with analgesics to reduce muscle pain) Refer to drugs that paralyze skeletal muscles (no effect on , gut, other smooth muscle, and labour) Do not produce analgesia, amnesia, nor sleep/unconsciousness directly. Profound muscle paralysis for surgical access and ease. Allow control of breathing in critically ill patients. Allow airway paralysis for ease of securing the airway (for intubation and ventilation. First way: depolarization of muscle fibres in an irreversible action (depolarizing muscle relaxant) When 2 ach molecules are bound to the receptor, membrane channels open to cause an influx of. Na and outflux of k depolarization of the end plate membrane. Describe the mechanism of action, effects + side effects, and critically consider the rationale use of the depolarizing muscle relaxant, Structurally similar to ach (looks like 2 ach molecules attached together) Mimics the action of ach: it attaches to neuromuscular end plate and causes depolarization, muscle fibres twitch.
