BIOL 454 Lecture Notes - Lecture 2: Bohr Effect, Swim Bladder, Partial Pressure

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6 Jan 2017
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Oxygen transport cascade: ventilation, pulmonary diffusion, perfusion, tissue diffusion, cellular metabolism. If one step is eliminated = death: symorphosis = looked at how these steps are matched in sedentary animals and elite athletes, co2 = produced by tissue and eliminated by the same pathway. O2 released to capillaries and at v = oxygen is released and down to 50% saturation and partial pressure will fall at around 35mmhg. Bohr effect = co2 being delivered to tissue acidifying the blood and enhancing: dotted blue line is if there is slight acidification, not very big difference (about 2mm hg) The slight increase in partial pressure will enhance the oxygen delivery. Can also trace at the same partial pressure, how much saturation of o2 has changed = tells how much more oxygen is being delivered. Pretty modest (5-10% increase: metabolically co2 produced bohr effect, enhances oxygen delivery (humans around 2%) Hb is one of the well-understood proteins.

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