BIOL 200 Lecture Notes - Lecture 4: Tumor Suppressor Gene, Oncogene, Phenotype
Document Summary
Protooncogenes becomes mutated to oncogenes which promote cell division and inhibit cell death (apoptosis). Gain of function mutation because it starts to divide more and it is a dominant mutation. Tumor suppressor genes is a loss of function mutation and it is a recessive mutation, both alleles need to be affected. Controls cell division, you can inherit the mutation. B inhibits transcription of a , loss of gene b then factor a will be hyper active and will upregular gene which promotes cell cycle and leads to cancer. 1. 1st pairing r b r b (need common denominator (1/3 of total) and normalize each for 1/3 of total) r b phenotype 1/2 rb 4/20. Rrbb 4/60 rrbb red 4/10 rb 1/2 4/20 rb 4/60 rb red 1/2 rb 4/20 rrbb 4/60 rrbb blue 4/10 rb 1/2 4/20 rb 4/60 rb blue 1/2 rb.
