BIOC 302 Lecture Notes - Lecture 5: Hydrophobic Effect, Ionic Strength, London Dispersion Force
Document Summary
Bmp + atp bdp + adp nucleoside diphosphate kinases. Step 2: the protonated 2" oh is very unstable. Step 3: forms a carbocaion that is very hungry for electrons. Step 3: the 2" carbon is fully reduced the next steps return the enzyme to resing state. Don"t worry about all the informaion in step 6. Thymidylate synthase is speciic for dump and adds a methyl group to form dtmp. Plp is the enzyme that transfers the carbon group. Don"t worry about tetrahydrofolate but note that it is made from folic acid we need it from our diet. To make a dinucleoide, the phosphate is esteriied to the 3"-oh of another nucleoide. You have to think about direcionality: 5" 3". 4 possibliies per spot 48 = 65356. Rna decays very fast the 2"oh is very close to the phosphorus atom. The oxygen performs a nucleophilic atack on the phosphorus and breaks the polymer.
