BIOC 202 Lecture Notes - Lecture 4: Gibbs Free Energy, Carboxylic Acid, Thermodynamics

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Second law of thermodynamics & entropy (s) aka randomness. [h+], ph and the role of ph on biological systems. Weak acids & bases, pka, and the henderson hasselbalch equation. Structure: amino, carboxyl, c , and r groups: ionization. Grouping the 20 amino acids ( : non-polar & aliphatic amino acids, aromatic amino acids, basic (positively charged) amino acids, acid (negatively charged) amino acids, polar amino acids. Now if we titrate a weak acid (ex acetic acid) with a strong base (naoh), we see fig 2- We can calculate the ph of any solution, if the molar ratio of acid to conjugate base and the pka is known through henderson-hasselbalch equation. ph = pka + log [a-]/[ha] Now if we look at the titration curve again, we notice something very useful. Buffer: a mixture of weak acid and conjugate base. It resists changes in ph because both forms are present.

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