CNUR 204 Lecture Notes - Lecture 4: Renal Function, Renal Replacement Therapy, Water–Electrolyte Imbalance

• School: University of Regina
• Department: Collaborative Nursing Program
• Course: CNUR 204
• Professor: Kelsie Neilson

Document Summary

A slow progressive disease progress; can lose up to 80% of kidney function before s&s show; develops over months-years. Defined as a gfr < 60 ml/min for 3 months consecutively or longer or 60% People often don"t notice the early stages because functioning nephrons hypertrophy to compensate. When gfr <15 mls/min rrt (renal replacement therapy) may be indicated. Dm (increase rate of filtration = decrease effectiveness of gfr. Persistent itching (high levels of urea that can"t be filtered, create almost a frost on skin that is very itchy) Peripheral edema (fluid retention, lytes/albumin lost = shifts into third space) As renal function deteriorates, excretory, regulatory and endocrine function are lost = imbalance in endocrine system (chems, hormones, bp) Retained substances include (urea, creatinine, phenols, hormones, electrolytes, water, etc) Changes in urine output (direct link with . As kidney disease worsens, oliguria develops and eventually anuria (output of 40 ml or less in 24 hours)