PSYCH261 Lecture Notes - Lecture 4: Living Brain, Autoradiograph, Diffusion Mri
4 Apr 2016
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Document Summary
The removal or destruction of a portion of the brain of a laboratory animal; presumably, the functions that can no longer be performed are the ones the region previously controlled. Excitotoxic lesion: a brain lesion produced by intercerebral injection of an excitatory amino acid, such as kainic acid (kills cells only at location and not fibers in region) 6-hydroxydopamine (6hd): a chemical that is selectively taken up by axons and terminal buttons of noradrenergic neurons and acts as a poison, damaging or killing them. Stereotaxic apparatus determines deep locations from superficial landmarks in human neurosurgery, animal research. Landmarks include skull features like the bregma. Stain (cresyl violet) good distinction between grey and white matter. Anterograde trace afferent neurons: pha-l, note the a. Functional techniques: fmri = different magnetic moment and sees what blood is oxygenated and how much blood is flowing to certain parts of the brain, pet = positron emission tomography, shows active areas in certain task.
