KIN406 Lecture Notes - Lecture 5: Mitochondrial Biogenesis, Nadh Dehydrogenase, Atp Synthase
13 Mar 2017
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Mitochondria structure, function & dysfunction in skeletal muscle. Because of type of metabolism to produce their atp. In general, mitochondria are distributed throughout the cytoplasm in a non- random fashion. In 1963, dna was discovered in the mitochondria (mtdna: the matrix of the mitochondria contains a small genome of 16569 base pairs (humans) 95% is coding, so more chances of: a mutation would happen in a non-coding region is. In contrast, in mendelian genetics, a mutation is only heterozygous or homozygous: the threshold for symptoms is usually above 70% mutation expression, mutations can effect a variety of tissues but are most common in post-mitotic. In skeletal muscle, mitochondrial are distributed in primarily two distinct locations. Interspersed between the myofibrils (intermyofibrillar mitochonidria; imf: although dependent on fiber type, imf mitochondria make up approximately. 75% of the total mitochondrial content whereas ss make up the remaining. Imf mitochondria have a higher rate of respiration (greater rate of.
