KIN406 Lecture Notes - Lecture 2: Intel 8089, Quadriceps Femoris Muscle, Extensor Digitorum Muscle
13 Mar 2017
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Document Summary
Type of stem cell and specific to muscle. Includes an embryonic form and a fetal forms myosin form is replaced by adult myosin: these fibers will develop into adult type i or type ii muscle. Formation of skeletal myotubes: when they fuse together and form a tube that is multinucleated and once they fuse they can no longer divide. Myoblast to myotube transition: how does this transition from myoblast to myotube occur, upregulation in the expression of important muscle specific transcription factors, myf genes (myogenic factor 5 (myf-5); myogenic determination (myod); myogenin) Myod/myf-5 deficiency: myod/myf-5 deficient mice lack any sign of skeletal muscle during development, this is due to a lack of myoblast proliferation and differentiation. If needed, satellite cells become activated, divide and fuse to replace or add nuclei to the muscle fiber. Skeletal muscle aging: age related loss in muscle mass (sarcopenia: comparing a 21 year old and 63 year old.
