KIN242 Lecture Notes - Lecture 3: Complement Membrane Attack Complex, Posterior Spinal Artery, Anterior Spinal Artery
13 Mar 2017
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Document Summary
Types of forces that cause sci: 1. Contusion (most common type): bruise within spinal cord, initial damage is caused by bleeding and causes pressure on neuron and cell death, 2. Compression: pressure on the spinal cord from outside source (e. g. tumour, fracture, adjacent hematoma, mechanical pressure = cell death (1+2 are most responsible for cell death, 3. Concussion: sudden trauma to tissue around spinal cord, usually temporary (hours, 4. Neurons die in one of two ways: 1. Necrosis: damaged cells swell and burst, can lead to death of surrounding tissue due to inflammatory processes, inflammation damages cells around, 2. Apoptosis (cid:494)cell suicide(cid:495: damaged cells eliminated themselves in controlled way, less damage to other cells surrounding. Sci secondary insult: a number of events may contribute, 1. Demyelination: demyelinated nerves that survive sci will be ineffective, speed of propagation of neural signals is much slower. Characterizing sci: complete lesion, no sensation and motor control below the injury is preserved.
