HLTH340 Lecture Notes - Lecture 2: Toxicokinetics, Xenobiotic, Physiologically Based Pharmacokinetic Modelling
25 Sep 2017
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Document Summary
Def: quantitative study of the movement of an exogenous chemical from its entry into the body through the distribution via blood circulation, and to its final disposition by way of biotransformation and excretion. The study relies on quantitation (mathematical modelling of the time course of disposition of a toxicant in the body) A reflection of how the body handles toxicants, indicated by plasma concentration of that xenobiotic in the body at various time points. End result is a biologically effective dose (amount of the compound that reaches the target site to cause a biologic effect) This is the amount that will undergo toxicodynamic processes that will determine the final effect on the body. Process that get the toxicant from point a (external dose) to point b (biologically active dose: absorption. Entry of the xenobiotics through external barriers into the blood or lymphatic circulation: distribution. Movement of xenobiotic molecules to specific organs and tissues within the body: metabolism.
