HLTH340 Lecture Notes - Lecture 1: Treatment As Prevention, Nephrotoxicity, Olestra
15 Sep 2017
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The study of poisons (inherent capacity of a chemical to produce injury) More detailed definitions : study of the adverse effects of agents on organisms and the ecosystem, study of the harmful effects of substances found in the environment, study of adverse or untoward effects of chemicals on biological systems. Adverse effects can occur over various timelines (acute to chronic) and have varying effects on the body (whole body down to a single cell) It is impossible to sort chemicals into good and bad . dose is the deciding factor between them being helpful and harmful. Records of ancient civilizations indicate recipes for various kinds of poisons. Paracelsus (1493-1541) something not to be poisonous : all things are poison, and nothing is without poison; only the dose permits, established the dose-response relationship. Mathieu orfila (1787-1853: father of toxicology, performed autopsies to determine organ and tissue damage.
