GERON255 Lecture Notes - Lecture 18: Geron Corporation, Ultimate Tensile Strength, Elastic Fiber
19 Apr 2016
School
Department
Course
Professor
Document Summary
Premise with age we have an a new formation of cross-links between or within macromolecules. It leads to conformational changes to the macromolecules which render them non-functional. Leads to dysfunction of cells, tissues, and organs. Glucose appears to be the cross-linker in the most situations. Collagen is most affected protein in the cell: major non-enzymatic protein in the body, major connective tissue of the body, makes up 30% of the total body protein. 4 major tissue types: connective** found throughout the body, most abundant by weight. Most common cell type and star shaped in nature. Produce the protein fibres that make up the matrix of the connective tissue. Types of protein fibres produced by fibroblasts: 1. Runs throughout the tissue like cables, holding structures together: 2. More in nature than collagen less strength than collagen but more flexible. Important in tissues that require flexibility (skin, lungs etc. ) Immune cells that destroy foreign particles in defence.
