CHEM237 Lecture Notes - Lecture 20: De Novo Synthesis, Trans Fat, Oxyanion Hole
12 Jul 2017
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Dietary supplements: a: ala epa and dha = omega 3 fatty acids (in brains, b: arachidonic acid is a signalling lipid for: 1: prostaglandins (acid damage protection, inflammation, uterine contractions) Triacylglycerols: 3 ester linked fatty acids + glycerol (his and ser therefore similar to serine proteases) 1: pancreatic lipase in intestine cleave: triacylglycerols 3 fatty acids + glycerol. 2: cellular lipase hydrolyze: triacylglycerols fatty acids for b oxidation. Sugars: carry more energy per c (reduced, carry less water (non-polar, long term energy storage/ slow delivery, carry less energy per c (oxidised, carry more water (polar, short term energy needs/ fast delivery. 1: plasmalogen: vinyl ether analog of phospha-tidyl-ethanol-amine: found in heart tissue, is resistant to common lipase cleavage, increase membrane rigidity. 2: platelet activating factor: aliphatic ether analog of phospha-tidyl-choline: esterified c2, signalling lipid, stimulates clotting and mediates inflammation. Blood groups: are determined by the head groups in glycosphingolipids, sugar structure is determined by expression of glycosyltransferases.
