BIOL444 Lecture Notes - Rhodococcus Equi, Hans Zinsser, Smallpox
25 Dec 2012
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Document Summary
Medical microbiology: study of interactions b/w animals (humans) & microorganisms (pathogens) w. r. t disease. Germ theory of disease (pasteur 19th century): Set 01 koch"s postulates: argued microbes were responsible for diseases, food spoilage & fermentations, developed vaccine for rabies. Jenner (1796): cowpox derived smallpox vaccine (milkmaids" complexion) Microbial caused diseases have influenced history: rats, lice & history hans zinsser typhus 1935 (rickettsia prowazeki) Diseases ended up deciding the winning side of war. Koch"s postulates (1882): the golden standard for proving causal relationship b/w microorganism & specific disease. Microorganism must be present at the site of infection in every case of the disease but absent from healthy individuals: asymptomatic carrier : individual that carries pathogen but do not exhibit symptoms of disease. Can transmit the pathogens to others that then may become diseased: opportunistic pathogens: cause disease only when the person is compromised. Hiv die from common infections due to compromised immune system; hospital secondary infections; skin lesions.
