BIOL373 Lecture Notes - Lecture 29: Paramesonephric Duct, Mesonephric Duct, Sertoli Cell
2 Sep 2019
School
Department
Course
Professor
Document Summary
Steps in sexual differentiation: build indifferent" gonads, differentiate gonads down either male or female pathway, requires expression of master gene on y chromosome, Sry : testes: germ cell precursors plus two major somatic cell types. Urinary and reproductive systems are inter-related: build three pairs of kidneys, first two sets degenerate, each sex forms para mesonephric ducts, but only retained in female, male uses ductwork left from primitive kidney. Mesonephric duct: female uses parallel ductwork - paramesonephric duct. Development of internal genitalia: wolffian derivatives, epididymis, vas (ductus) deferens, accessory sex glands, m llerian derivatives, oviducts (fallopian tubes, uterus, cervix, upper vagina. Development: build bipotential" gonad, germ cell precursors arrive, somatic cells organize around them. Disorders of sexual differentiation: predict the outcome in the following (loss of function) gene mutations, 5 -reductase in xy individual, 21-hydroxylase in xx individual, androgen receptor in xy individual. Hypothalamic-pituitary-gonadal (hpg) axis: gnrh = gonadotropin releasing hormone, lh = luteinizing hormone, fsh = follicle-stimulating hormone.
