BIOL303 Lecture Notes - Lecture 8: Asymmetric Cell Division, Ring Finger Domain, Cell Cortex
3 Oct 2017
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Topic 8: c. elegans: recall c. elega(cid:374)s uses (cid:862)type o(cid:374)e(cid:863) e(cid:373)(cid:271)ryoge(cid:374)esis, rapid specification of blastomeres by products of zygotic genes and by maternally provided. Small enough to be used for microscopy techniques where we can see all the cells: 99% of the population are hermaphrodites, males are very rare. Invariant embryonic development c. elegans adult male or hermaphrodites display an exact number of cells that arise through reproducible patterns of cell divisions. Some spreading and perdurance of the rnai effect into the next generation: c. elegans has hox genes tgf-b, wnt, and notch signaling pathways that were found by exhaustive. No hedgehog: gene silencing by antisense rna and rna interference. Double stranded molecule introduced exogenously and chopped up by a dicer into short rnais. These are now sirna and are picked up by risc, can now be used as a template to chop up the corresponding mrna.
