What is microbiology: microorganism are very small, unicellular organisms that cannot be seen through the naked eye. Microbes: bacteria interact with different organisms, interaction between rhizobium bacteria and plants is one of the most important in the world because it converts nitrogen gas to ammonia which provides nutrients to plants. Precursors to macromolecules (sugar, amino acid, fatty acid, etc. : genetic machines (have coding functions) Where do microorganisms come from: theory of spontaneous generation. Designed a long necked flask where non sterile liquid was poured, liquid sterilized by repeated heated, then cooled and left for many years, Pasteur knew that no microorganism were growing because of the liquid remaining were clears. After the liquid came into contact with the dust, microorganism grew. Proof that spontaneous generations did not exist. Experiment were done by bacillus anthraces, microorganism causes anthrax, Observation showed that blood of diseased rat contained bacterial cells as well as rbc.