BIOL130 Lecture Notes - Lecture 2: Drinking Straw, Spindle Apparatus, Protein Superfamily
20 Apr 2017
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Centrosome (2 centrioles: role unclear organization of mitotic/ meiotic spindle apparatus, basal body at base of cilia/ flagella. Prokaryotes and cytoskeletons: once thought to be a feature of eukaryotes only, recent advances in microscopy have shown tht prokaryotes do have some organization ex. Binary fission move chromosomes: found tht there are comparable elements of cytoskeleton in prokaryotes that play similar roles as in eukaryotes. Cross section of intestinal mucosa: epithelium tissue, connective tissue, muscle tissue, neural tissue, tight junctions sealing certain proteins above and bellow the junction, basal layer basement membrane, microtubules hollow tubes of protein called. Add spindle poison tht interferes with tubulin polymerization: drugs tht affect microtubules, taxol binds and stabilize microtubules, colchicine, colcemid, vinblastine, vincristine binds tubulin dimers and prevents their polymerization. Antimitotic chemotherapy for cancer tht stops, tubulin polyermizaton/ uncontrolled division. Interacting b/w these proto-filaments are motor proteins use dynein and kinesin.
