BIOL130 Lecture Notes - Lecture 1: Cell Membrane, Hydrophile, Signal Transduction
16 Dec 2016
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Slide 3: e(cid:374)do(cid:272)ri(cid:374)e = (cid:862)pu(cid:271)li(cid:272)(cid:863) neuronal long range but private (telephone) paracrine less public contact dependent extremely private (whispering in ear!) Signals can act over a long or shot range. **differences lie in speed + selectivity with which signals are delivered to their targets. Slide4: typical cell expresses many types of receptors, each present in 10s to hundreds of thousands of copies. Acetylcholine is a simple signal but it bind to different target cells, triggering different responses: is a ligand-gated channel. Each cell responds to a limited set of signals: without an appropriate acceptor, cell is deaf to signal --> therefore producing a limited set of receptors on cell = restricting the types of signals that can affect it. Signal molecules change target cell --> shape, movement, metabolism, gene expression. Signal to cell surface --> conveyed inside the target cell by intracellular signaling molecules --> alter activity of effector proteins (change behaviour of cell)
