PHPY 304 Lecture Notes - Lecture 1: Enterohepatic Circulation, Cytochrome P450, Grapefruit Juice
4 Dec 2016
School
Department
Course
Professor
Document Summary
What the body dose to the drug. What the drug dose to the body. Define pharmacokinetics, pharmacodynamics, pka, bioavailability, clearance, volume of distribution, and half-life. List factors affecting absorption, distribution, metabolism and excretion of drugs. Recall the effect of ph on acidic and basic drugs, ion trapping and its clinical significance with one example. Recall the impact of plasma protein of drugs on drug-drug interactions: give examples of two organs with differences in capillary permeability. List the characteristics of the blood:brain barrier and its clinical significance with one example: recite the significance of vd values (low and high values, recall the definition (purpose) of drug metabolism. Describe the phases of drug metabolism and the main chemical reactions in each phase. List the characteristics of cytochrome p450 enzymes and conjugating enzymes: define a prodrug. List the characteristics and clinical significance of p-glycoprotein: recall the effect of enterohepatic recirculation on half-life and give one example of the clinical significance of enterohepatic recirculation.
