NUTR 120 Lecture Notes - Lecture 21: Megaloblastic Anemia, Neural Tube Defect, Cobalamin
Document Summary
Not a lack of dietary b12 but it clinically looks like megaloblastic anemia. It is caused by a lack of intrinsic factor: caused by a genetic problem, often occurs in the elderly, they have a decreased ability to make if. 1991 disco(cid:448)ery of supple(cid:373)e(cid:374)ts of folate reduced risk for ntd"s i(cid:374) preg(cid:374)a(cid:374)t (cid:449)o(cid:373)a(cid:374) Consider: of pregnancies are unplanned, build/optimize body folate levels takes time, 1st 14-21 days post conception is when closure of neural tube occurs. Beriberi deficiency disease caused by a lack of vit b1 thiamin. Milk and cheese are good sources of riboflavin and vit b12 cobalamin. Only found in animal products: cobalamin vit b12. Deficiency causes megaloblastic anemia : vit b12 cobalamin and folate. Deficiency causes irreversible nerve damage: vit b12 cobalamin. Toxicity includes permanent numbness/tingling: vit b6 pyridoxine. Pellagra deficiency disease is caused by niacin. Cofactor in reactions involving amino acids: vit b6 pyridoxine. 16th century, hawkins discovered that oranges and lemons prevented/cured scurvy.
