ACB 334 Lecture Notes - Lecture 2: Neural Crest, Neural Groove, Neural Fold
14 Nov 2018
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L2: development of the brain and spinal cord. Neural plate is evident at 4. 5-5 days post-conception. 3 main germ layers evident at 15 embryonic days. Neural plate is just starting to fold forms neural groove. Pressure from growth of underlying mesoderm (pushes up on ectoderm) Future neural crest cells at neural folds. Neural groove closes beginning of neural tube, neural crest cells pinch off, and surface ectoderm joins together. Closes like a zipper in rostral and caudal direction. *folic acid is important for women of child bearing age for proper neural development. Somites = bumps on the side of neural tube: 31 paired body segments. Cranial/caudal neuropores = open connection w/ amniotic cavity: closes by the end of 4th week, the bumps on each side of the fused neural tube are. *the cells of the neural tube give rise to cells of the cns: neurons (brain and spinal cord, glia (astrocytes, oligodendrocytes, microglia, ependyma)
