MBIO 4440 Lecture 6: Vaginal Microbiome
30 Jan 2019
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Document Summary
1r2 and tnf- may play a role in how a woman responds to a particular microbial challenge: women with cst-iv-like states show significant increases in interleukins and ifn- . How the immune system surveils the vaginal microbiota: pattern recognition receptors (prrs) such as toll-like receptors (tlrs) and. Nod factors: additional factors contributing to vaginal defense include mannose binding lectin (mbl), vaginal antimicrobial peptides (amps) and immunoglobulin a and g (iga, igg). Dysbiosis: an imbalance of the microbial community characterized by quantitative and/or qualitative changes in: The local distribution of its members: bv is a dysbiosis of the vaginal microbiota in reproductive-age women with unknown etiology and poorly understood pathogenesis. For women with lactobacillus-dominated microbiota, there is a depletion of lactobacilli and an overgrowth of anaerobic bv-associated bacteria (bvab). The roles of different lactobacilli in preventing or promoting the transition to dysbiosis are an increasing area of investigation: during bv, the vaginal environment grows diverse anaerobic bacteria and higher bacterial load.
