MBIO 2420 Lecture Notes - Lecture 30: Heparan Sulfate, Immunoglobulin Superfamily, On2 Technologies

• School: University of Manitoba
• Department: Microbiology
• Course: MBIO 2420
• Professor: Dr.Peter Pelka

Document Summary

Derived from host during egress: during exit of host. External domains contain binding sites for cell surface receptors, major antigen determinants, fusion sequences. Appear as a regular spherical structure in em. Proteins ordered within tegument due to direct contacts with proteins in nucleocapsid and enveloped glycoproteins. Proteins within the tegument initiate the lytic cycle. Viral genomes are packaged within protective protein capsids. Proteins associate in highly regular arrays in two basic symmetries. Formed by assembly of identical structural units: helical. Capsids may be rigid or flexible, filamentous looking. All animal viruses with helical capsids contain an envelope. Simplest way of making a spherical shell with maximal internal volume. Viruses with icosahedral capsids do not require an envelope. A single protein (vp5) forms the capsid. There are some proteins we do not know. One genome packaged per capsid: linear, but in the cell it circularizes. Two unique regions: long (ul, short (us)