MBIO 2420 Lecture Notes - Lecture 21: Concatemer, Antigen-Presenting Cell, T Cell
7 Dec 2016
School
Department
Course
Professor
Document Summary
Different than other viruses in the priming stage. Needs dntps from the cell: all initiation cell cycle - is to make dntps. Hadv encodes its own polymerase, factors, and primers: pre-terminal protein (ptp) Linked to a nucleotide - c - and initiates transcription. Viral genome has a protein attached to both ends. Protects end of degradation and evade the immune system. No concatemers - genomes are linked together: dna binding protein (dbp, dna pol, doesn"t rely on any cellular factors - just need dntps. One area base pairs with one another: have another initiation by ptp and dna pol. It will remake the strand and displaces the dbp: then clip off the ptp and dna pol. Adenovirus is the only one that uses a protein primer: protection of viral genome, prevents dna damage. E3 proteins: the major function is for viral host immune evasion, and escape of virus from infected cell.
